Drug General Information
Drug ID	D00IWL
Former ID	DIB009029
Drug Name	PolyHeme
Synonyms	Oxygen-carrying blood substitute, Northfield Laboratories
Indication	Blood forming organ disorders [ICD10:D75.9]		Phase 3	[521584]
Company	Northfield Laboratories
Structure		Download 2D MOL
Target and Pathway
Target(s)	Hemoglobin	Target Info	Modulator	[544047]
KEGG Pathway	African trypanosomiasis
	Malaria
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Scavenging of heme from plasma
WikiPathways	Binding and Uptake of Ligands by Scavenger Receptors
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
	Factors involved in megakaryocyte development and platelet production
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 521584	ClinicalTrials.gov (NCT00076648) Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting. U.S. National Institutes of Health.
Ref 544047	Blood substitutes- the polyheme trials. Mcgill J Med. 2008 January; 11(1): 59-65.

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