Drug Information
Drug General Information | |||||
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Drug ID |
D00IFR
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Former ID |
DNCL002111
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Drug Name |
AZD1208
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Drug Type |
Small molecular drug
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Company |
AstraZeneca
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Structure |
Download2D MOL |
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Formula |
C21H21N3O2S
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InChI |
InChI=1S/C21H21N3O2S/c22-16-9-5-11-24(13-16)19-15(12-18-20(25)23-21(26)27-18)8-4-10-17(19)14-6-2-1-3-7-14/h1-4,6-8,10,12,16H,5,9,11,13,22H2,(H,23,25,26)/b18-12-/t16-/m1/s1
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InChIKey |
MCUJKPPARUPFJM-UWCCDQBKSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Serine/threonine-proteinkinase pim-2 | Target Info | Modulator | [532601] | |
KEGG Pathway | Acute myeloid leukemia | ||||
WikiPathways | Hematopoietic Stem Cell Differentiation | ||||
References | |||||
Ref 532601 | AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood. 2014 Feb 6;123(6):905-13. | ||||
Ref 542673 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7698). |
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