Drug Information

Drug General Information
Drug ID
D00HSO
Former ID
DCL000549
Drug Name
ISIS-5GLT2rx
Drug Type
Small molecular drug
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Investigative [551054]
Company
ISIS
Structure
Download
2D MOL

3D MOL
Formula
C17H12BrFN2O3
Canonical SMILES
C1=CC=C2C(=C1)C(=NN(C2=O)CC3=C(C=C(C=C3)Br)F)CC(=O)O
InChI
1S/C17H12BrFN2O3/c18-11-6-5-10(14(19)7-11)9-21-17(24)13-4-2-1-3-12(13)15(20-21)8-16(22)23/h1-7H,8-9H2,(H,22,23)
InChIKey
LKBFFDOJUKLQNY-UHFFFAOYSA-N
PubChem Compound ID
5278
PubChem Substance ID
5616278, 8153244, 11113738, 11120263, 11120751, 11121239, 11342114, 11362297, 11364377, 11366939, 11369501, 11371896, 11374993, 11377663, 11485129, 11487699, 11489283, 11490863, 11493002, 11495297, 12013115, 14829960, 17397894, 26680549, 29224333, 47364952, 50065127, 53530998, 57322692, 85789490, 85789665, 103123627, 103165638, 103922759, 104308777, 117389119, 124637034, 124886948, 128500409, 134339117, 134340376, 135011929, 135698020, 135727686, 137122051, 139060527, 142773112, 144204481, 162022632, 162655628
Target and Pathway
Target(s) Sodium/glucose cotransporter 2 Target Info Blocker [551054]
Reactome Hexose transport
Na+-dependent glucose transporters
Inositol transporters
WikiPathways NRF2 pathway
References
Ref 551054Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
Ref 551054Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).

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