Drug Information

Drug General Information
Drug ID
D00HNG
Former ID
DIB019157
Drug Name
CMPD-1
Synonyms
furan-1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538692]
Structure
Download
2D MOL
Formula
C30H37NO5
InChI
InChI=1S/C30H37NO5/c1-18-13-22-23(30(4,5)12-11-29(22,2)3)15-19(18)14-20-9-10-24(36-20)28(32)31-27-25(34-7)16-21(33-6)17-26(27)35-8/h9-10,13,15-17H,11-12,14H2,1-8H3,(H,31,32)
InChIKey
IPEMCIBPDYCJLO-UHFFFAOYSA-N
PubChem Compound ID
9957278
PubChem Substance ID
14932948, 24226250, 46053882, 76715728, 77580852, 85227419, 103621243, 104110398, 125752452, 135302055, 135650116, 135698622, 137832921, 139292582, 163123695, 204380663, 226564219, 241055628, 241376097, 245516949, 249617676, 252156745
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Antagonist [526554]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538692(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1179).
Ref 526554Biological characterization of a novel, orally active small molecule gonadotropin-releasing hormone (GnRH) antagonist using castrated and intact rats. J Pharmacol Exp Ther. 2003 May;305(2):688-95. Epub 2003 Jan 24.

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