Drug General Information
Drug ID	D00HBR
Former ID	DIB015545
Drug Name	AIKO-150
Synonyms	Opioid neutral antagonists (iv, pain), Aiko Biotechnology; 6-beta-naltrexol
Drug Type	Small molecular drug
Indication	Opiate dependence [ICD9: 304; ICD10:F11]		Phase 1	[522558]
Company	Aiko Biotechnology Inc
Structure		Download 2D MOL 3D MOL
Formula	C20H25NO4
Canonical SMILES	c1cc(c2c3c1C[C@@H]1[C@]4([C@@]3([C@H]([C@@H](CC4)O)O2)C<br />CN1CC1CC1)O)O
PubChem Compound ID	5486554
Target and Pathway
Target(s)	Mu-type opioid receptor	Target Info	Antagonist	[551690]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Estrogen signaling pathway
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Enkephalin release
Pathway Interaction Database	IL4-mediated signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	TCR Signaling Pathway
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Opioid Signalling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522558	ClinicalTrials.gov (NCT00829777) Safety Study of Intravenous 6??Naltrexol (AIKO-150) in Opioid-Dependent Subjects. U.S. National Institutes of Health.
Ref 551690	Clinical pipeline report, company report or official report of signaturerx.

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