Drug General Information
Drug ID	D00EZE
Former ID	DIB004442
Drug Name	Panamesine
Synonyms	EMD-57445; EMD-59983
Drug Type	Small molecular drug
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Discontinued in Phase 2	[544890]
Company	Merck KGaA
Structure		Download 2D MOL 3D MOL
Formula	C23H26N2O6
Canonical SMILES	C1(=O)N(C[C@@H](O1)CN1CCC(c2cc3c(OCO3)cc2)(CC1)O)c1ccc(<br />cc1)OC
CAS Number	CAS 139225-22-2
PubChem Compound ID	3047810
Target and Pathway
Target(s)	Sigma(1)-type opioid receptor	Target Info	Binder	[525495], [526642], [532713]
WikiPathways	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
References
Ref 544890	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001428)
Ref 525495	Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: an open clinical trial. Pharmacopsychiatry. 1999 Mar;32(2):68-72.
Ref 526642	Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.

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