Drug General Information
Drug ID	D00CVJ
Former ID	DNCL003143
Drug Name	Neu-P11
Drug Type	Small molecular drug
Indication	Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0]		Phase 2	[523722]
Company	Neurim Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Formula	C17H16N2O4
PubChem Compound ID	24815904
Target and Pathway
Target(s)	5-hydroxytryptamine 1A receptor	Target Info	Agonist	[551415]
	5-hydroxytryptamine 1D receptor	Target Info	Agonist	[551415]
	Melatonin receptor	Target Info	Agonist	[543744]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapsehsa04024:cAMP signaling pathway
	Serotonergic synapsehsa04080:Neuroactive ligand-receptor interaction
	Circadian entrainment
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
	G alpha (i) signalling events
WikiPathways	Serotonin HTR1 Group and FOS Pathway
	SIDS Susceptibility Pathways
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR downstream signaling
References
Ref 523722	ClinicalTrials.gov (NCT01489969) Sleep Laboratory Study to Investigate the Safety and Efficacy of Neu-P11 in Primary Insomnia Patients. U.S. National Institutes of Health.
Ref 543744	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 288).
Ref 551415	Clinical pipeline report, company report or official report of Neurim Pharmaceuticals.

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