Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00CGH
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| Former ID |
DIB003221
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| Drug Name |
RO-23-7553
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| Synonyms |
BXL-353; ILX-23-7553; (1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19),16-tetraen-23-yne-1,3,25-triol; 1alpha,25-Dihydroxy-16,17,23,23,24,24-hexadehydrocholecalciferol; 1alpha,25-Dihydroxy-16,17,23,23,24,24-hexadehydrovitamin D3
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| Drug Type |
Small molecular drug
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| Indication | Prostate disease [ICD10:N42.9] | Phase 1 | [521467] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C27H38O3
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| Canonical SMILES |
C[C@H](CC#CC(C)(C)O)C1=CC[C@H]2\\C(=C\\C=C/3\\C[C@@H](O<br />)C[C@H](O)C3=C)\\CCC[C@]12C
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| InChI |
1S/C27H38O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-12,18,22,24-25,28-30H,2,7-9,13,15-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,24+,25+,27-/m1/s1
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| InChIKey |
JKFZMIQMKFWJAY-RQJQXFIZSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Vitamin D receptor | Target Info | Agonist | [534747], [551871] | |
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Vitamin D metabolism and pathway | ||||
| References | |||||
| Ref 534747 | Three synthetic vitamin D analogues induce prostate-specific acid phosphatase and prostate-specific antigen while inhibiting the growth of human prostate cancer cells in a vitamin D receptor-dependent fashion. Clin Cancer Res. 1997 Aug;3(8):1331-8. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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