Drug Information

Drug General Information
Drug ID
D00BMF
Former ID
DCL000571
Drug Name
MK-4827
Drug Type
Small molecular drug
Indication Ovarian cancer [ICD9: 183; ICD10:C56] Phase 2 [523258], [543030]
Company
Merck
Structure
Download
2D MOL

3D MOL
Formula
C19H20N4O
InChI
InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
InChIKey
PCHKPVIQAHNQLW-CQSZACIVSA-N
PubChem Compound ID
24958200
PubChem Substance ID
56256045, 57487185, 103749792, 104150587, 135265184, 135626858, 136340151, 136349580, 136367711, 136946461, 137232464, 138192109, 144116229, 152258260, 160647096, 160829563, 162038124, 162113109, 163094037, 163394941, 163843781, 174007122, 186007055, 189561499, 198976487, 202829003, 204430248, 223617456, 227634434, 247056359, 249752894, 252080192, 252166487, 252227886, 252300335, 252462459
Target and Pathway
Target(s) Poly ADP ribose polymerase (PARP) Target Info Modulator [1572591]
References
Ref 523258ClinicalTrials.gov (NCT01244009) A Study of MK-4827 for the Treatment of Mantle Cell Lymphoma (MK-4827-002). U.S. National Institutes of Health.
Ref 543030(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8275).
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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