Drug General Information
Drug ID	D00AII
Former ID	DNC006561
Drug Name	(E)-4-(3,5-dimethoxystyryl)phenol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528198]
Structure		Download 2D MOL 3D MOL
Formula	C16H16O3
Canonical SMILES	COC1=CC(=CC(=C1)C=CC2=CC=C(C=C2)O)OC
InChI	1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
InChIKey	VLEUZFDZJKSGMX-ONEGZZNKSA-N
PubChem Compound ID	5281727
Target and Pathway
Target(s)	Proto-oncogene c-Abl	Target Info	Inhibitor	[528198]
KEGG Pathway	ErbB signaling pathway
	Ras signaling pathway
	Cell cycle
	Axon guidance
	Neurotrophin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Pathways in cancer
	MicroRNAs in cancer
	Chronic myeloid leukemia
	Viral myocarditis
PANTHER Pathway	Axon guidance mediated by Slit/Robo
Pathway Interaction Database	p73 transcription factor network
	ATM pathway
	Regulation of Telomerase
	Posttranslational regulation of adherens junction stability and dissassembly
	Lissencephaly gene (LIS1) in neuronal migration and development
	PDGFR-beta signaling pathway
	Neurotrophic factor-mediated Trk receptor signaling
	Validated transcriptional targets of TAp63 isoforms
	p53 pathway
	Regulation of retinoblastoma protein
Reactome	Regulation of actin dynamics for phagocytic cup formation
	CDO in myogenesis
	RHO GTPases Activate WASPs and WAVEs
	HDR through Single Strand Annealing (SSA)
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Fcgamma receptor (FCGR) dependent phagocytosis
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Pathogenic Escherichia coli infection
	Regulation of Microtubule Cytoskeleton
	Integrated Breast Cancer Pathway
	Signaling by Robo receptor
	Myogenesis
	Factors involved in megakaryocyte development and platelet production
References
Ref 528198	J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
Ref 528198	J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.

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