Drug Information

Drug General Information
Drug ID
DXZ4UG
Drug Name
(Z)-3-({3-[3-(Dimethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-5-(indolin-1-ylsulfonyl)indolin-2-one
Synonyms
CHEMBL1215348
Indication Discovery agent Investigative [1587926]
Formula
C30H32N4O4S
Canonical SMILES
CN(C)CCCc1c(\\C=C\\2/C(=O)Nc3ccc(cc23)S(=O)(=O)N4CCc5ccccc45)[nH]c6CCCC(=O)c16
InChI
InChI=1S/C30H32N4O4S/c1-33(2)15-6-8-21-26(31-25-9-5-11-28(35)29(21)25)18-23-22-17-20(12-13-24(22)32-30(23)36)39(37,38)34-16-14-19-7-3-4-10-27(19)34/h3-4,7,10,12-13,17-18,31H,5-6,8-9,11,14-16H2,1-2H3,(H,32,36)/b23-18-
InChIKey
WHFRCTYFOGGZAU-NKFKGCMQSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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