Drug Information

Drug General Information
Drug ID
DXXK1B
Drug Name
2-Methyl-2-[[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl](2,2,2-trifluoroethyl)amino]-1-propanol Hydrochloride
Synonyms
CHEMBL1650535
Indication Discovery agent Investigative [1587926]
Formula
C20H24ClF3N8OS
Canonical SMILES
Cl.Cc1cn2c(cnc2c(Nc3cc(CN(CC(F)(F)F)C(C)(C)CO)ns3)n1)c4cn[nH]c4
InChI
InChI=1S/C20H23F3N8OS.ClH/c1-12-8-31-15(13-5-25-26-6-13)7-24-18(31)17(27-12)28-16-4-14(29-33-16)9-30(10-20(21,22)23)19(2,3)11-32;/h4-8,32H,9-11H2,1-3H3,(H,25,26)(H,27,28);1H
InChIKey
MVSJDIKQVYOMNC-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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