Drug Information

Drug General Information
Drug ID
DXX1QZ
Drug Name
4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[4-(dimethylaminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine
Synonyms
CHEMBL1099347
Indication Discovery agent Investigative [1587926]
Formula
C34H33N7O
Canonical SMILES
CCn1cc(c2ccnc3[nH]c(cc23)c4ccc(CN(C)C)cc4)c(n1)c5ccc(NC(=O)Nc6ccccc6)cc5
InChI
InChI=1S/C34H33N7O/c1-4-41-22-30(32(39-41)25-14-16-27(17-15-25)37-34(42)36-26-8-6-5-7-9-26)28-18-19-35-33-29(28)20-31(38-33)24-12-10-23(11-13-24)21-40(2)3/h5-20,22H,4,21H2,1-3H3,(H,35,38)(H2,36,37,42)
InChIKey
BQYUDMQJOHMTEM-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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