Drug Information
| Drug General Information | |||||
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| Drug ID |
DXW7OL
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| Drug Name |
(Z)-5-{6-[3-(4-Chlorophenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl}-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
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| Synonyms |
CHEMBL1172421
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C23H19ClN4O4
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| Canonical SMILES |
Cc1[nH]c(\\C=C\\2/C(=O)Nc3cc(NC(=O)Nc4ccc(Cl)cc4)ccc23)c(C)c1C(=O)O
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| InChI |
InChI=1S/C23H19ClN4O4/c1-11-18(25-12(2)20(11)22(30)31)10-17-16-8-7-15(9-19(16)28-21(17)29)27-23(32)26-14-5-3-13(24)4-6-14/h3-10,25H,1-2H3,(H,28,29)(H,30,31)(H2,26,27,32)/b17-10-
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| InChIKey |
RWCSLXSUPQHKBX-YVLHZVERSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| FL cytokine receptor | Target Info | [1587926] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04060:Cytokine-cytokine receptor interaction | |||||
| Hematopoietic cell lineage | |||||
| Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Acute myeloid leukemia | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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