Drug Information
| Drug General Information | |||||
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| Drug ID |
DXV07L
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| Drug Name |
(3R,5S)-5-((4-(3-chloro-4-(3-fluorophenylthio)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL501050
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H25ClFN5O3S2
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| Canonical SMILES |
Fc1cccc(Sc2ccc(Nc3ncnc4cc(C#C[C@@H]5C[C@H](CN5)OC(=O)N6CCOCC6)sc34)cc2Cl)c1
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| InChI |
InChI=1S/C29H25ClFN5O3S2/c30-24-14-20(5-7-26(24)40-22-3-1-2-18(31)12-22)35-28-27-25(33-17-34-28)15-23(41-27)6-4-19-13-21(16-32-19)39-29(37)36-8-10-38-11-9-36/h1-3,5,7,12,14-15,17,19,21,32H,8-11,13,16H2,(H,33,34,35)/t19-,21-/m1/s1
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| InChIKey |
RJZPDKUWHMCJNM-TZIWHRDSSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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