Drug Information

Drug General Information
Drug ID
DXTZ0O
Drug Name
N-(2-(2-(3-(trifluoromethyl)phenylamino)-1H-benzo[d]imidazol-6-yl)ethyl)thieno[3,2-d]pyrimidin-4-amine
Synonyms
CHEMBL1080981
Indication Discovery agent Investigative [1587926]
Formula
C22H17F3N6S
Canonical SMILES
FC(F)(F)c1cccc(Nc2nc3ccc(CCNc4ncnc5ccsc45)cc3[nH]2)c1
InChI
InChI=1S/C22H17F3N6S/c23-22(24,25)14-2-1-3-15(11-14)29-21-30-16-5-4-13(10-18(16)31-21)6-8-26-20-19-17(7-9-32-19)27-12-28-20/h1-5,7,9-12H,6,8H2,(H,26,27,28)(H2,29,30,31)
InChIKey
AHPOODNBWXPMQB-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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