Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXS3FE
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| Drug Name |
(Z)-(5-{6-[3-(4-Methoxyphenyl)-ureido]-2-oxo-1,2-dihydroindol-3-ylidene-methyl}-2,4-dimethyl-1H-pyrrol-3-yl)acetic acid
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| Synonyms |
CHEMBL1173150
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C25H24N4O5
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| Canonical SMILES |
COc1ccc(NC(=O)Nc2ccc3\\C(=C\\c4[nH]c(C)c(CC(=O)O)c4C)\\C(=O)Nc3c2)cc1
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| InChI |
InChI=1S/C25H24N4O5/c1-13-19(12-23(30)31)14(2)26-21(13)11-20-18-9-6-16(10-22(18)29-24(20)32)28-25(33)27-15-4-7-17(34-3)8-5-15/h4-11,26H,12H2,1-3H3,(H,29,32)(H,30,31)(H2,27,28,33)/b20-11-
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| InChIKey |
FUNGTOAZDDISQB-JAIQZWGSSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| FL cytokine receptor | Target Info | [1587926] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04060:Cytokine-cytokine receptor interaction | |||||
| Hematopoietic cell lineage | |||||
| Pathways in cancer | |||||
| Transcriptional misregulation in cancer | |||||
| Acute myeloid leukemia | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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