Drug Information
| Drug General Information | |||||
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| Drug ID |
DXR4UH
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| Drug Name |
5-[4-(3-Chloro-4-fluoro-phenylamino)-7-methyl-6-oxo-6,7-dihydro-pyrrolo[2,3-d]pyrimidin-(5Z)-ylidenemethyl]-4-methyl-1H-pyrrole-2-carboxylic acid (2-morpholin-4-yl-ethyl)-amide
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| Synonyms |
CHEMBL443268
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C26H27ClFN7O3
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| Canonical SMILES |
CN1C(=O)\\C(=C/c2[nH]c(cc2C)C(=O)NCCN3CCOCC3)\\c4c(Nc5ccc(F)c(Cl)c5)ncnc14
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| InChI |
InChI=1S/C26H27ClFN7O3/c1-15-11-21(25(36)29-5-6-35-7-9-38-10-8-35)33-20(15)13-17-22-23(30-14-31-24(22)34(2)26(17)37)32-16-3-4-19(28)18(27)12-16/h3-4,11-14,33H,5-10H2,1-2H3,(H,29,36)(H,30,31,32)/b17-13-
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| InChIKey |
VZVRWQGDDKSERZ-LGMDPLHJSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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