Drug Information

Drug General Information
Drug ID
DXQJ9S
Drug Name
[3-Hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl]-carbamic acid tert-butyl ester
Synonyms
CHEMBL138953
Indication Discovery agent Investigative [1587926]
Formula
C22H27N3O7S
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)N2Cc3cc(NC(=O)OC(C)(C)C)ccc3CC2C(=O)NO
InChI
InChI=1S/C22H27N3O7S/c1-22(2,3)32-21(27)23-16-6-5-14-12-19(20(26)24-28)25(13-15(14)11-16)33(29,30)18-9-7-17(31-4)8-10-18/h5-11,19,28H,12-13H2,1-4H3,(H,23,27)(H,24,26)
InChIKey
PBJWRLBRUGJQMR-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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