| Drug General Information |
| Drug ID |
DXP5US
|
| Drug Name |
{4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid
|
| Synonyms |
CHEMBL37495
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C20H16F3NO4S
|
| Canonical SMILES |
Cc1nc(oc1CSc2ccc(OCC(=O)O)cc2)c3ccc(cc3)C(F)(F)F
|
| InChI |
InChI=1S/C20H16F3NO4S/c1-12-17(11-29-16-8-6-15(7-9-16)27-10-18(25)26)28-19(24-12)13-2-4-14(5-3-13)20(21,22)23/h2-9H,10-11H2,1H3,(H,25,26)
|
| InChIKey |
JWWDUIBPFIEOPE-UHFFFAOYSA-N
|
| Target and Pathway |
| Target(s) |
Peroxisome proliferator activated receptor gamma |
Target Info |
|
[1]
|
|---|
| Peroxisomeproliferator activated receptor delta |
Target Info |
|
[1]
|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
AMPK signaling pathway
|
|
Osteoclast differentiation
|
|
Huntington's disease
|
|
Pathways in cancer
|
|
Transcriptional misregulation in cancer
|
|
Thyroid cancerhsa03320:PPAR signaling pathway
|
|
Wnt signaling pathway
|
|
Acute myeloid leukemia
|
|
NetPath Pathway
|
IL1 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
Leptin Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
CCKR signaling map STP00057:Wnt signaling pathway
|
|
Pathway Interaction Database
|
Noncanonical Wnt signaling pathway
|
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
Signaling events mediated by HDAC Class I
|
|
RXR and RAR heterodimerization with other nuclear receptor
|
|
Regulation of retinoblastoma proteinps1pathway:Presenilin action in Notch and Wnt signaling
|
|
Reactome
|
PPARA activates gene expression
|
|
Transcriptional regulation of white adipocyte differentiation
|
|
Nuclear Receptor transcription pathwayR-HSA-200425:Import of palmitoyl-CoA into the mitochondrial matrix
|
|
Regulation of pyruvate dehydrogenase (PDH) complex
|
|
Nuclear Receptor transcription pathway
|
|
WikiPathways
|
Wnt Signaling Pathway Netpath
|
|
Nuclear Receptors in Lipid Metabolism and Toxicity
|
|
Differentiation of white and brown adipocyte
|
|
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Transcriptional Regulation of White Adipocyte Differentiation
|
|
Adipogenesis
|
|
SREBP signalling
|
|
Nuclear ReceptorsWP399:Wnt Signaling Pathway and Pluripotency
|
|
NRF2 pathway
|
|
Nuclear Receptors Meta-Pathway
|
|
Vitamin D Receptor Pathway
|
|
Ectoderm Differentiation
|
|
Nuclear Receptors
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
