Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXN8XR
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| Drug Name |
[3-Methyl-1-(3-{4-methyl-2-[(quinoline-7-carbonyl)-amino]-pentanoylamino}-4-oxo-pyrrolidin-1-ylmethyl)-butyl]-carbamic acid benzyl ester
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| Synonyms |
CHEMBL350591
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C34H43N5O5
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| Canonical SMILES |
CC(C)C[C@@H](CN1CC(NC(=O)[C@H](CC(C)C)NC(=O)c2ccc3cccnc3c2)C(=O)C1)NC(=O)OCc4ccccc4
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| InChI |
InChI=1S/C34H43N5O5/c1-22(2)15-27(36-34(43)44-21-24-9-6-5-7-10-24)18-39-19-30(31(40)20-39)38-33(42)29(16-23(3)4)37-32(41)26-13-12-25-11-8-14-35-28(25)17-26/h5-14,17,22-23,27,29-30H,15-16,18-21H2,1-4H3,(H,36,43)(H,37,41)(H,38,42)/t27-,29-,30?/m0/s1
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| InChIKey |
DLJDOHHQJSCLFD-CVYBXRIJSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | RANKL/RANK Signaling Pathway | ||||
| Osteoclast Signaling | |||||
| References | |||||
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