Drug Information

Drug General Information
Drug ID
DXN6VG
Drug Name
[2-(Dibenzofuran-2-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid
Synonyms
CHEMBL434655
Indication Discovery agent Investigative [1587926]
Formula
C23H17NO6S
Canonical SMILES
OC(=O)C(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc4oc5ccccc5c4c3
InChI
InChI=1S/C23H17NO6S/c25-22(23(26)27)19-11-14-5-1-2-6-15(14)13-24(19)31(28,29)16-9-10-21-18(12-16)17-7-3-4-8-20(17)30-21/h1-10,12,19H,11,13H2,(H,26,27)
InChIKey
PVTAZXXDKDMCRE-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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