Drug Information

Drug General Information
Drug ID
DXN5SK
Drug Name
{2-[4-(4-Methylcarbamoyl-phenoxy)-benzenesulfonyl]-1,2,3,4-tetrahydro-isoquinolin-3-yl}-oxo-acetic acid
Synonyms
CHEMBL141835
Indication Discovery agent Investigative [1587926]
Formula
C25H22N2O7S
Canonical SMILES
CNC(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)N3Cc4ccccc4CC3C(=O)C(=O)O)cc1
InChI
InChI=1S/C25H22N2O7S/c1-26-24(29)16-6-8-19(9-7-16)34-20-10-12-21(13-11-20)35(32,33)27-15-18-5-3-2-4-17(18)14-22(27)23(28)25(30)31/h2-13,22H,14-15H2,1H3,(H,26,29)(H,30,31)
InChIKey
DNFKKMGBEKWECE-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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