Drug Information

Drug General Information
Drug ID
DXLS7X
Drug Name
Oxo-[2-(4-[1,2,3]triazol-2-yl-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-acetic acid
Synonyms
CHEMBL141470
Indication Discovery agent Investigative [1587926]
Formula
C19H16N4O5S
Canonical SMILES
OC(=O)C(=O)C1Cc2ccccc2CN1S(=O)(=O)c3ccc(cc3)n4nccn4
InChI
InChI=1S/C19H16N4O5S/c24-18(19(25)26)17-11-13-3-1-2-4-14(13)12-22(17)29(27,28)16-7-5-15(6-8-16)23-20-9-10-21-23/h1-10,17H,11-12H2,(H,25,26)
InChIKey
LKFQHLGPHTXZAW-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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