Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXLI3Q
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| Drug Name |
methyl N-(5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-3a-aza-2-indolyl)carbamate
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| Synonyms |
CHEMBL243915
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C23H17F4N5O4
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| Canonical SMILES |
COC(=O)Nc1cn2cc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)ccc2n1
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| InChI |
InChI=1S/C23H17F4N5O4/c1-35-22(34)31-19-12-32-11-16(7-9-20(32)30-19)36-15-5-3-14(4-6-15)28-21(33)29-18-10-13(23(25,26)27)2-8-17(18)24/h2-12H,1H3,(H,31,34)(H2,28,29,33)
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| InChIKey |
XXMJXRZJNGKMJK-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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