Drug Information

Drug General Information
Drug ID
DXL9A5
Drug Name
2,2,2-trifluoro-1-(5-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)thiophen-2-yl)ethanone
Synonyms
CHEMBL461333
Indication Discovery agent Investigative [1587926]
Formula
C13H6F3N3O2S
Canonical SMILES
FC(F)(F)C(=O)c1ccc(s1)c2onc(n2)c3ccncc3
InChI
InChI=1S/C13H6F3N3O2S/c14-13(15,16)10(20)8-1-2-9(22-8)12-18-11(19-21-12)7-3-5-17-6-4-7/h1-6H
InChIKey
LMQNGVNXXKVSAT-UHFFFAOYSA-N
Target and Pathway
Target(s) Histone deacetylase 6 Target Info [1587926]
Histone deacetylase 4 Target Info [1587926]
KEGG Pathway Alcoholism
Viral carcinogenesishsa05034:Alcoholism
Epstein-Barr virus infection
Viral carcinogenesis
MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class III
Signaling events mediated by HDAC Class I
Sumoylation by RanBP2 regulates transcriptional repression
Validated nuclear estrogen receptor alpha network
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Assembly of the primary ciliumR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
WikiPathways Ectoderm Differentiation
Neural Crest Differentiation
Cell CycleWP474:Endochondral Ossification
Cardiac Hypertrophic Response
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
TarBasePathway
Cell Cycle
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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