| Drug General Information |
| Drug ID |
DXJC5C
|
| Drug Name |
2-methyl-2-(4-(3-(1-(4-methylbenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)propyl)phenoxy)propanoic acid
|
| Synonyms |
CHEMBL149676
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C26H33N3O4
|
| Canonical SMILES |
CCCN1C(=NN(Cc2ccc(C)cc2)C1=O)CCCc3ccc(OC(C)(C)C(=O)O)cc3
|
| InChI |
InChI=1S/C26H33N3O4/c1-5-17-28-23(27-29(25(28)32)18-21-11-9-19(2)10-12-21)8-6-7-20-13-15-22(16-14-20)33-26(3,4)24(30)31/h9-16H,5-8,17-18H2,1-4H3,(H,30,31)
|
| InChIKey |
AOGHSWJOFVVPJI-UHFFFAOYSA-N
|
| Target and Pathway |
| Target(s) |
Peroxisome proliferator activated receptor gamma |
Target Info |
|
[1]
|
|---|
| Peroxisomeproliferator activated receptor delta |
Target Info |
|
[1]
|
|
KEGG Pathway
|
PPAR signaling pathway
|
|
AMPK signaling pathway
|
|
Osteoclast differentiation
|
|
Huntington's disease
|
|
Pathways in cancer
|
|
Transcriptional misregulation in cancer
|
|
Thyroid cancerhsa03320:PPAR signaling pathway
|
|
Wnt signaling pathway
|
|
Acute myeloid leukemia
|
|
NetPath Pathway
|
IL1 Signaling Pathway
|
|
TGF_beta_Receptor Signaling Pathway
|
|
Leptin Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
CCKR signaling map STP00057:Wnt signaling pathway
|
|
Pathway Interaction Database
|
Noncanonical Wnt signaling pathway
|
|
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
|
Signaling events mediated by HDAC Class I
|
|
RXR and RAR heterodimerization with other nuclear receptor
|
|
Regulation of retinoblastoma proteinps1pathway:Presenilin action in Notch and Wnt signaling
|
|
Reactome
|
PPARA activates gene expression
|
|
Transcriptional regulation of white adipocyte differentiation
|
|
Nuclear Receptor transcription pathwayR-HSA-200425:Import of palmitoyl-CoA into the mitochondrial matrix
|
|
Regulation of pyruvate dehydrogenase (PDH) complex
|
|
Nuclear Receptor transcription pathway
|
|
WikiPathways
|
Wnt Signaling Pathway Netpath
|
|
Nuclear Receptors in Lipid Metabolism and Toxicity
|
|
Differentiation of white and brown adipocyte
|
|
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
|
Transcriptional Regulation of White Adipocyte Differentiation
|
|
Adipogenesis
|
|
SREBP signalling
|
|
Nuclear ReceptorsWP399:Wnt Signaling Pathway and Pluripotency
|
|
NRF2 pathway
|
|
Nuclear Receptors Meta-Pathway
|
|
Vitamin D Receptor Pathway
|
|
Ectoderm Differentiation
|
|
Nuclear Receptors
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
