Drug Information
| Drug General Information | |||||
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| Drug ID |
DXJ4W2
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| Drug Name |
{4-(1-Benzyl-1H-indazol-5-ylamino)-5-ethyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl}-carbamic acid 2-(piperidin-1-yl)ethyl ester
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| Synonyms |
CHEMBL566350
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C30H34N8O2
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| Canonical SMILES |
CCC1=C2C(N=CN=C2Nc3ccc4c(cnn4Cc5ccccc5)c3)N=C1NC(=O)OCCN6CCCCC6
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| InChI |
InChI=1S/C30H34N8O2/c1-2-24-26-28(34-23-11-12-25-22(17-23)18-33-38(25)19-21-9-5-3-6-10-21)31-20-32-29(26)35-27(24)36-30(39)40-16-15-37-13-7-4-8-14-37/h3,5-6,9-12,17-18,20,29H,2,4,7-8,13-16,19H2,1H3,(H,31,32,34)(H,35,36,39)
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| InChIKey |
VDEFSHMEYOAABL-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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