Drug Information
| Drug General Information | |||||
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| Drug ID |
DXI3OK
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| Drug Name |
(S)-3,3-dimethyl-1-(4-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)butan-2-yl (S)-2-oxo-1-(pyridine-2-sulfonamido)heptan-3-ylcarbamate
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| Synonyms |
CHEMBL393673
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H36F3N5O5S
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| Canonical SMILES |
CCCC[C@H](NC(=O)O[C@H](Cn1cc(cn1)c2ccc(cc2)C(F)(F)F)C(C)(C)C)C(=O)CNS(=O)(=O)c3ccccn3
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| InChI |
InChI=1S/C29H36F3N5O5S/c1-5-6-9-23(24(38)17-35-43(40,41)26-10-7-8-15-33-26)36-27(39)42-25(28(2,3)4)19-37-18-21(16-34-37)20-11-13-22(14-12-20)29(30,31)32/h7-8,10-16,18,23,25,35H,5-6,9,17,19H2,1-4H3,(H,36,39)/t23-,25+/m0/s1
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| InChIKey |
GMHBWGMFTPGDOI-UKILVPOCSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | RANKL/RANK Signaling Pathway | ||||
| Osteoclast Signaling | |||||
| References | |||||
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