Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXH8LE
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| Drug Name |
3-(2-(2-aminopyrimidin-5-yl)ethynyl)-N-(3-(trifluoromethyl)-phenyl)benzamide
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| Synonyms |
CHEMBL375819
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C20H13F3N4O
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| Canonical SMILES |
Nc1ncc(cn1)C#Cc2cccc(c2)C(=O)Nc3cccc(c3)C(F)(F)F
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| InChI |
InChI=1S/C20H13F3N4O/c21-20(22,23)16-5-2-6-17(10-16)27-18(28)15-4-1-3-13(9-15)7-8-14-11-25-19(24)26-12-14/h1-6,9-12H,(H,27,28)(H2,24,25,26)
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| InChIKey |
FDWJEDYUZLTROC-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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