Drug Information

Drug General Information
Drug ID
DXH4TB
Drug Name
1-[5-Chloro-2-(2-dimethylamino-1-methyl-ethoxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea
Synonyms
CHEMBL425904
Indication Discovery agent Investigative [1587926]
Formula
C17H19ClN6O2
Canonical SMILES
CC(CN(C)C)Oc1ccc(Cl)cc1NC(=O)Nc2cnc(cn2)C#N
InChI
InChI=1S/C17H19ClN6O2/c1-11(10-24(2)3)26-15-5-4-12(18)6-14(15)22-17(25)23-16-9-20-13(7-19)8-21-16/h4-6,8-9,11H,10H2,1-3H3,(H2,21,22,23,25)
InChIKey
IODANOYNIPFWFE-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Serine/threonine-protein kinase Chk1 Target Info [1587926]
KEGG Pathway Oocyte meiosishsa04110:Cell cycle
p53 signaling pathway
HTLV-I infection
Viral carcinogenesis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingfanconi_pathway:Fanconi anemia pathway
p73 transcription factor network
ATR signaling pathway
Circadian rhythm pathway
p53 pathway
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-176187:Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP707:DNA Damage Response
Signaling by SCF-KIT
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Cancer pathway
Cell Cycle
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage Response
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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