Drug Information

Drug General Information
Drug ID
DXH0XO
Drug Name
[5-(2-Fluoro-phenyl)-3-(1H-indol-3-ylmethyl)-3H-benzo[e][1,4]diazepin-2-ylamino]-acetic acid
Synonyms
CHEMBL315184
Indication Discovery agent Investigative [1587926]
Formula
C26H21FN4O2
Canonical SMILES
OC(=O)CNC1=Nc2ccccc2C(=N[C@@H]1Cc3c[nH]c4ccccc34)c5ccccc5F
InChI
InChI=1S/C26H21FN4O2/c27-20-10-4-1-8-18(20)25-19-9-3-6-12-22(19)31-26(29-15-24(32)33)23(30-25)13-16-14-28-21-11-5-2-7-17(16)21/h1-12,14,23,28H,13,15H2,(H,29,31)(H,32,33)/t23-/m1/s1
InChIKey
VTLYHPYOFGZVPC-HSZRJFAPSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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