Drug Information

Drug General Information
Drug ID
DXGR6V
Drug Name
4-((4-(but-2-ynyloxy)phenylsulfonyl)methyl)-1-(3,5-dichloroisonicotinoyl)-N-hydroxypiperidine-4-carboxamide
Synonyms
CHEMBL391881
Indication Discovery agent Investigative [1587926]
Formula
C23H23Cl2N3O6S
Canonical SMILES
CC#CCOc1ccc(cc1)S(=O)(=O)CC2(CCN(CC2)C(=O)c3c(Cl)cncc3Cl)C(=O)NO
InChI
InChI=1S/C23H23Cl2N3O6S/c1-2-3-12-34-16-4-6-17(7-5-16)35(32,33)15-23(22(30)27-31)8-10-28(11-9-23)21(29)20-18(24)13-26-14-19(20)25/h4-7,13-14,31H,8-12,15H2,1H3,(H,27,30)
InChIKey
IDHBZDJZPPEMGC-UHFFFAOYSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Collagenase 3 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancer
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling PathwayNetPath_13:IL1 Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventsupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
Assembly of collagen fibrils and other multimeric structures
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP474:Endochondral Ossification
Oncostatin M Signaling Pathway
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.