Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXG3RK
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| Drug Name |
(+)-1-((1R,3R)-3-hydroxycyclopentyl)-3-(4-methoxyphenyl)-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
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| Synonyms |
Ro-4383596; CHEMBL1952210
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C24H25N5O3
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| Canonical SMILES |
COc1ccc(cc1)N2Cc3cnc(Nc4ccccc4)nc3N([C@@H]5CC[C@@H](O)C5)C2=O
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| InChI |
InChI=1S/C24H25N5O3/c1-32-21-11-8-18(9-12-21)28-15-16-14-25-23(26-17-5-3-2-4-6-17)27-22(16)29(24(28)31)19-7-10-20(30)13-19/h2-6,8-9,11-12,14,19-20,30H,7,10,13,15H2,1H3,(H,25,26,27)/t19-,20-/m1/s1
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| InChIKey |
NDEFXZOKPREYOV-WOJBJXKFSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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