Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXE1ZO
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| Drug Name |
1-(3-(2-aminoquinazolin-6-yl)-4-methylphenyl)-3-(3-(trifluoromethyl)phenyl)urea
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| Synonyms |
CHEMBL409914
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C23H18F3N5O
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| Canonical SMILES |
Cc1ccc(NC(=O)Nc2cccc(c2)C(F)(F)F)cc1c3ccc4nc(N)ncc4c3
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| InChI |
InChI=1S/C23H18F3N5O/c1-13-5-7-18(30-22(32)29-17-4-2-3-16(10-17)23(24,25)26)11-19(13)14-6-8-20-15(9-14)12-28-21(27)31-20/h2-12H,1H3,(H2,27,28,31)(H2,29,30,32)
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| InChIKey |
BIPPSOZOQMDQPZ-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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