Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXA8OP
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| Drug Name |
4-methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)benzamide
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| Synonyms |
CHEMBL276395
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H26F3N5O2
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| Canonical SMILES |
Cc1ccc(cc1Oc2ncccc2c3ccncn3)C(=O)Nc4cc(ccc4N5CCCCC5)C(F)(F)F
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| InChI |
InChI=1S/C29H26F3N5O2/c1-19-7-8-20(16-26(19)39-28-22(6-5-12-34-28)23-11-13-33-18-35-23)27(38)36-24-17-21(29(30,31)32)9-10-25(24)37-14-3-2-4-15-37/h5-13,16-18H,2-4,14-15H2,1H3,(H,36,38)
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| InChIKey |
QLGAQJUHADDMHQ-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
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