Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXA8FV
|
||||
| Drug Name |
(R)-N-(1-cyano-cyclopropyl)-3-methanesulfonyl-2-[(S)-2,2,2-trifluoro-1-(4'-fluoro-biphenyl-4-yl)-ethylamino]-propionamide
|
||||
| Synonyms |
CHEMBL248889
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C22H21F4N3O3S
|
||||
| Canonical SMILES |
CS(=O)(=O)C[C@H](N[C@@H](c1ccc(cc1)c2ccc(F)cc2)C(F)(F)F)C(=O)NC3(CC3)C#N
|
||||
| InChI |
InChI=1S/C22H21F4N3O3S/c1-33(31,32)12-18(20(30)29-21(13-27)10-11-21)28-19(22(24,25)26)16-4-2-14(3-5-16)15-6-8-17(23)9-7-15/h2-9,18-19,28H,10-12H2,1H3,(H,29,30)/t18-,19-/m0/s1
|
||||
| InChIKey |
ZBNVNRCRULQVAR-OALUTQOASA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | RANKL/RANK Signaling Pathway | ||||
| Osteoclast Signaling | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.