Drug Information

Drug General Information
Drug ID
DX8ZLK
Drug Name
3-((1R,5S)-8-oxa-3-azabicyclo[3.2.1]octan-3-ylmethyl)-N-(6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)isothiazol-5-amine
Synonyms
CHEMBL1269988
Indication Discovery agent Investigative [1587926]
Formula
C20H22N8OS
Canonical SMILES
Cc1cn2c(cnc2c(Nc3cc(CN4C[C@H]5CC[C@@H](C4)O5)ns3)n1)c6cn[nH]c6
InChI
InChI=1S/C20H22N8OS/c1-12-8-28-17(13-5-22-23-6-13)7-21-20(28)19(24-12)25-18-4-14(26-30-18)9-27-10-15-2-3-16(11-27)29-15/h4-8,15-16H,2-3,9-11H2,1H3,(H,22,23)(H,24,25)/t15-,16+
InChIKey
GTVYEMJXACMSGJ-IYBDPMFKSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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