Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX8C7G
|
||||
| Drug Name |
N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-6-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine
|
||||
| Synonyms |
CHEMBL468618
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C25H20F3N7O
|
||||
| Canonical SMILES |
CNc1nccc(n1)c2cccnc2Oc3ccc(Nc4nc5ccc(cc5[nH]4)C(F)(F)F)cc3C
|
||||
| InChI |
InChI=1S/C25H20F3N7O/c1-14-12-16(32-24-34-19-7-5-15(25(26,27)28)13-20(19)35-24)6-8-21(14)36-22-17(4-3-10-30-22)18-9-11-31-23(29-2)33-18/h3-13H,1-2H3,(H,29,31,33)(H2,32,34,35)
|
||||
| InChIKey |
ATRPQMWXVVIWMO-UHFFFAOYSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Angiopoietin 1 receptor | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathwayP00005:Angiogenesis | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.