Drug Information

Drug General Information
Drug ID
DX7YUS
Drug Name
(2R,5R)-5-Hydroxy-1-[4-(isoquinolin-1-ylmethoxy)-benzenesulfonyl]-3,3-dimethyl-piperidine-2-carboxylic acid hydroxyamide
Synonyms
CHEMBL189975
Indication Discovery agent Investigative [1587926]
Formula
C24H27N3O6S
Canonical SMILES
CC1(C)C[C@@H](O)CN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(OCc3nccc4ccccc34)cc2
InChI
InChI=1S/C24H27N3O6S/c1-24(2)13-17(28)14-27(22(24)23(29)26-30)34(31,32)19-9-7-18(8-10-19)33-15-21-20-6-4-3-5-16(20)11-12-25-21/h3-12,17,22,28,30H,13-15H2,1-2H3,(H,26,29)/t17-,22+/m1/s1
InChIKey
XVBKVNVPXQZYQF-VGSWGCGISA-N
Target and Pathway
Target(s) Collagenase 3 Target Info [1587926]
Interstitial collagenase Target Info [1587926]
KEGG Pathway PPAR signaling pathway
Pathways in cancer
Bladder cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
EGFR1 Signaling Pathway
TWEAK Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathway
Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Plasminogen activating cascade
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingendothelinpathway:Endothelins
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
Syndecan-1-mediated signaling events
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WikiPathways Endochondral Ossification
Activation of Matrix Metalloproteinases
Oncostatin M Signaling Pathway
AGE/RAGE pathway
Matrix MetalloproteinasesWP366:TGF beta Signaling Pathway
Bladder Cancer
Degradation of collagen
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell surface interactions at the vascular wall
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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