Drug Information

Drug General Information
Drug ID
DX7BDB
Drug Name
[3-(3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinoline-2-sulfonyl)-phenyl]-carbamic acid 4-methoxy-phenyl ester
Synonyms
CHEMBL344029
Indication Discovery agent Investigative [1587926]
Formula
C24H23N3O7S
Canonical SMILES
COc1ccc(OC(=O)Nc2cccc(c2)S(=O)(=O)N3Cc4ccccc4CC3C(=O)NO)cc1
InChI
InChI=1S/C24H23N3O7S/c1-33-19-9-11-20(12-10-19)34-24(29)25-18-7-4-8-21(14-18)35(31,32)27-15-17-6-3-2-5-16(17)13-22(27)23(28)26-30/h2-12,14,22,30H,13,15H2,1H3,(H,25,29)(H,26,28)
InChIKey
IGJDRNDPWLIBBQ-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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