Drug Information

Drug General Information
Drug ID
DX5WVD
Drug Name
4-[6-Methoxy-7-(3-piperidin-1-yl-propoxy)-quinazolin-4-yl]-piperazine-1-carbothioic acid (5-methyl-furan-2-ylmethyl)-amide
Synonyms
CHEMBL184129
Indication Discovery agent Investigative [1587926]
Formula
C28H38N6O3S
Canonical SMILES
COc1cc2c(ncnc2cc1OCCCN3CCCCC3)N4CCN(CC4)\\C(=N/Cc5oc(C)cc5)\\S
InChI
InChI=1S/C28H38N6O3S/c1-21-7-8-22(37-21)19-29-28(38)34-14-12-33(13-15-34)27-23-17-25(35-2)26(18-24(23)30-20-31-27)36-16-6-11-32-9-4-3-5-10-32/h7-8,17-18,20H,3-6,9-16,19H2,1-2H3,(H,29,38)
InChIKey
OAPAVRKVRIDCGV-UHFFFAOYSA-N
Target and Pathway
Target(s) Beta platelet-derived growth factor receptor Target Info [1587926]
Mast/stem cell growth factor receptor Target Info [1587926]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
Regulation of actin cytoskeleton
HTLV-I infection
Pathways in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04014:Ras signaling pathway
Endocytosis
Hematopoietic cell lineage
Melanogenesis
Acute myeloid leukemia
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling Pathway
PANTHER Pathway Angiogenesis
PDGF signaling pathway
Pathway Interaction Database Signaling events mediated by PTP1B
Beta3 integrin cell surface interactions
S1P3 pathway
Nectin adhesion pathway
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
PDGFR-beta signaling pathway
Validated targets of C-MYC transcriptional repression
PDGF receptor signaling networkcmyb_pathway:C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome PIP3 activates AKT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
Regulation of KIT signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
MAPK Signaling Pathway
Osteoblast Signaling
Focal Adhesion
PIP3 activates AKT signaling
PDGF Pathway
Signaling Pathways in Glioblastoma
Signaling by PDGFWP304:Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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