Drug Information
| Drug General Information | |||||
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| Drug ID |
DX5W6R
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| Drug Name |
(3R,5S)-5-((4-(1-(1-(3-fluorophenyl)ethyl)-1H-indazol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL503253
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C32H30FN7O3S
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| Canonical SMILES |
CC(c1cccc(F)c1)n2ncc3cc(Nc4ncnc5cc(C#C[C@@H]6C[C@H](CN6)OC(=O)N7CCOCC7)sc45)ccc23
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| InChI |
InChI=1S/C32H30FN7O3S/c1-20(21-3-2-4-23(33)13-21)40-29-8-6-25(14-22(29)17-37-40)38-31-30-28(35-19-36-31)16-27(44-30)7-5-24-15-26(18-34-24)43-32(41)39-9-11-42-12-10-39/h2-4,6,8,13-14,16-17,19-20,24,26,34H,9-12,15,18H2,1H3,(H,35,36,38)/t20?,24-,26-/m1/s1
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| InChIKey |
OMNUQQMMTVDCHE-JYHRCJKBSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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