Drug Information

Drug General Information
Drug ID
DX4WEB
Drug Name
[7-Amino-2-(4'-chloro-biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-yl]-oxo-acetic acid
Synonyms
CHEMBL140439
Indication Discovery agent Investigative [1587926]
Formula
C23H19ClN2O5S
Canonical SMILES
Nc1ccc2CC(N(Cc2c1)S(=O)(=O)c3ccc(cc3)c4ccc(Cl)cc4)C(=O)C(=O)O
InChI
InChI=1S/C23H19ClN2O5S/c24-18-6-1-14(2-7-18)15-4-9-20(10-5-15)32(30,31)26-13-17-11-19(25)8-3-16(17)12-21(26)22(27)23(28)29/h1-11,21H,12-13,25H2,(H,28,29)
InChIKey
NKTGQIQCKMXEOS-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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