Drug Information
| Drug General Information | |||||
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| Drug ID |
DX4SNT
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| Drug Name |
(2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-fluorobenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)quinazolin-6-yl]but-2-enamide
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| Synonyms |
CHEMBL428741
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H28FN5O5
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| Canonical SMILES |
CCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)OCc4cccc(F)c4)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C29H28FN5O5/c1-4-39-26-14-21-20(12-23(26)33-28(38)9-6-10-35(2)3)29(32-17-31-21)34-22-13-25(37)27(15-24(22)36)40-16-18-7-5-8-19(30)11-18/h5-9,11-15,17H,4,10,16H2,1-3H3,(H,33,38)(H,31,32,34)/b9-6+
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| InChIKey |
XRLIPUSFUDXFGS-RMKNXTFCSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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