Drug Information

Drug General Information
Drug ID
DX4PYK
Drug Name
4-(1-Benzyl-2-phenyl-ethylamino)-N,N-bis-(3-dimethylamino-propyl)-3-nitro-benzenesulfonamide
Synonyms
CHEMBL434341
Indication Discovery agent Investigative [1587926]
Formula
C31H43N5O4S
Canonical SMILES
CN(C)CCCN(CCCN(C)C)S(=O)(=O)c1ccc(NC(Cc2ccccc2)Cc3ccccc3)c(c1)[N+](=O)[O-]
InChI
InChI=1S/C31H43N5O4S/c1-33(2)19-11-21-35(22-12-20-34(3)4)41(39,40)29-17-18-30(31(25-29)36(37)38)32-28(23-26-13-7-5-8-14-26)24-27-15-9-6-10-16-27/h5-10,13-18,25,28,32H,11-12,19-24H2,1-4H3
InChIKey
QDNZGMZTGONDEP-UHFFFAOYSA-N
Target and Pathway
Target(s) B1 bradykinin receptor Target Info [1587926]
B2 bradykinin receptor Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Pathways in cancerhsa04020:Calcium signaling pathway
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Chagas disease (American trypanosomiasis)
Pathways in cancer
NetPath Pathway Leptin Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database Direct p53 effectors
Validated transcriptional targets of deltaNp63 isoforms
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways Complement and Coagulation Cascades
ACE Inhibitor Pathway
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP554:ACE Inhibitor Pathway
Nifedipine Activity
GPCR downstream signaling
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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