Drug Information

Drug General Information
Drug ID
DX4FRZ
Drug Name
(Z)-5-(Indolin-1-ylsulfonyl)-3-{[3-(3-morpholino-3-oxopropyl)-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl]methylene}indolin-2-one
Synonyms
CHEMBL1215283
Indication Discovery agent Investigative [1587926]
Formula
C32H32N4O6S
Canonical SMILES
O=C(CCc1c(\\C=C\\2/C(=O)Nc3ccc(cc23)S(=O)(=O)N4CCc5ccccc45)[nH]c6CCCC(=O)c16)N7CCOCC7
InChI
InChI=1S/C32H32N4O6S/c37-29-7-3-5-26-31(29)22(9-11-30(38)35-14-16-42-17-15-35)27(33-26)19-24-23-18-21(8-10-25(23)34-32(24)39)43(40,41)36-13-12-20-4-1-2-6-28(20)36/h1-2,4,6,8,10,18-19,33H,3,5,7,9,11-17H2,(H,34,39)/b24-19-
InChIKey
HMUZWZQGRIJSCT-CLCOLTQESA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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