Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX3FYJ
|
||||
| Drug Name |
4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(4-phenyl-thiazol-2-ylmethyl)-phenylamino]-3-cyano-7-methoxy-quinolin-6-yl}-amide
|
||||
| Synonyms |
CHEMBL360979
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C33H29ClN6O2S
|
||||
| Canonical SMILES |
COc1cc2ncc(C#N)c(Nc3ccc(Cc4nc(cs4)c5ccccc5)c(Cl)c3)c2cc1NC(=O)\\C=C\\CN(C)C
|
||||
| InChI |
InChI=1S/C33H29ClN6O2S/c1-40(2)13-7-10-31(41)38-28-16-25-27(17-30(28)42-3)36-19-23(18-35)33(25)37-24-12-11-22(26(34)15-24)14-32-39-29(20-43-32)21-8-5-4-6-9-21/h4-12,15-17,19-20H,13-14H2,1-3H3,(H,36,37)(H,38,41)/b10-7+
|
||||
| InChIKey |
CJOFPUIXYQYKPH-JXMROGBWSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.