Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX2ZJS
|
||||
| Drug Name |
4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(phenylaminomethyl-amino)-phenylamino]-3-cyano-7-methoxy-quinolin-6-yl}-amide
|
||||
| Synonyms |
CHEMBL178096
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C30H30ClN7O2
|
||||
| Canonical SMILES |
COc1cc2ncc(C#N)c(Nc3ccc(NCNc4ccccc4)c(Cl)c3)c2cc1NC(=O)\\C=C\\CN(C)C
|
||||
| InChI |
InChI=1S/C30H30ClN7O2/c1-38(2)13-7-10-29(39)37-27-15-23-26(16-28(27)40-3)33-18-20(17-32)30(23)36-22-11-12-25(24(31)14-22)35-19-34-21-8-5-4-6-9-21/h4-12,14-16,18,34-35H,13,19H2,1-3H3,(H,33,36)(H,37,39)/b10-7+
|
||||
| InChIKey |
ZVJKJOPDVJJONM-JXMROGBWSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.