Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX2DFZ
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| Drug Name |
(2E)-4-(dimethylamino)-N-{7-ethoxy-4-[(4-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)amino]quinazolin-6-yl}but-2-enamide
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| Synonyms |
CHEMBL428039
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C23H25N5O5
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| Canonical SMILES |
CCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)OC)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C23H25N5O5/c1-5-33-20-11-15-14(9-17(20)26-22(31)7-6-8-28(2)3)23(25-13-24-15)27-16-10-19(30)21(32-4)12-18(16)29/h6-7,9-13H,5,8H2,1-4H3,(H,26,31)(H,24,25,27)/b7-6+
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| InChIKey |
QYZCYYQLUANKGJ-VOTSOKGWSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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